Substance	Tacrolimus
Brand name:	Protopic
Description
	Immunosuppressive Drug
	Prophylactic treatment of moderate to severe atopic dermatitis to prevent sudden exacerbations of the disease and increase the duration of periods of remission
Brands:	Protopic, Envarsus XR, Astagraf XL, And Prograf
Availability:	Prescription needed
Pregnancy:	Consult a doctor
Alcohol:	Not detected with light alcohol consumption
Side Effects:	Flushing, Acid Or Sour Stomach, Fever
Interactions:	Unknown
For informational purposes only. Consult your local medical authority for advice.

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What may interact with Protopic?

It is not likely that other drugs you take orally or inject will have an effect on topically applied tacrolimus topical. But an interaction may occur if you apply tacrolimus over large skin areas. Tell your doctor about all other medicines you use, especially:

• conivaptan (Vaprisol);

• imatinib (Gleevec);

• isoniazid (for treating tuberculosis);

• an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);

• an antidepressant such as nefazodone;

• antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend);

• heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);

• HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);

This list is not complete and other drugs may interact with tacrolimus topical. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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